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Modapro (Modafinil)

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Modapro is used to treat excessive sleepiness caused by narcolepsy or shift work sleep disorder (sleepiness during scheduled waking hours and difficulty falling asleep or staying asleep during scheduled sleeping hours.

Other names for this medication:
Alertec, Carim, Dekast, Modafinil, Modafinilo, Modalert, Modapro, Modatec, Modavigil, Modfil, Modiodal, Provake, Renea, Vigia

Similar Products:
Zovirax, Diamox, Aygestin, Requip, Lanoxin, Duricef, Amoxil, Albenza, Zolpel, Cymbalta, Rivadem, Tromix, Roxate, Brustin, Tenace, Metrofur, Disalunil,

Also known as: Modafinil


How you take Modapro may depend on what you’re taking it for.


If you’re taking Modapro to reduce daytime sleepiness due to narcolepsy or sleep apnea, you’ll take it in the morning.

If you’re taking Modapro for shift work sleep disorder, you’ll likely take it one hour before your work shift.

Modapro will keep you awake for several hours, so you shouldn’t take it too close to your bedtime.

Taking Modapro with food

You can take Modapro with or without food. If the drug upsets your stomach, taking it with food might reduce this side effect. However, if you take it with food, Modapro might take slightly longer to start working.

Can Modapro be crushed?

Modapro tablets should not be crushed or split. If you’re having trouble taking Modapro, talk to your doctor or pharmacist about options that can make swallowing the tablet easier.


Dosage for adults is 100 mg per day. Take with or without food.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Modapro are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Modapro if you have ever had an allergic reaction or skin rash while taking modafinil or armodafinil (Nuvigil).

To make sure Modapro is safe for you, tell your doctor if you have:

angina (chest pain); cirrhosis or other liver problem; kidney disease; high blood pressure, heart disease, or history of heart attack; a history of mental illness or psychosis; or history of alcoholism or drug addiction.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Modapro can make certain birth control less effective. Hormonal contraception (birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment. Talk with your doctor about the best methods of birth control to use while taking Modapro.

It is not known whether modafinil passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Modapro is not approved for use by anyone younger than 17 years old.

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Some of the key processes involved in the formation of aerial hyphae by these microbes appear to be very similar. Alterations in GABA(A) receptor expression in neonatal ventral hippocampal lesioned rats: comparison of prepubertal and postpubertal periods. Caregivers of patients with longer illness histories reported higher levels of positive caregiving appraisals. The hypothalamic melanocortin system, which includes neurons that produce pro-opiomelanocortin (POMC)-derived peptides, is a major negative regulator of energy balance. With the expertise from vertebral compression fracture reduction by kyphoplasty, we examined in a cadaver feasibility study whether reduction of the Hill-Sachs lesion via hydraulic lift might be an anatomical and minimally invasive treatment option. By initiating regional care networks, ClaudicatioNet aims to improve the quality of care for patients with IC. Numerous preclinical studies have demonstrated the efficacy of recombinant adeno-associated virus (rAAV) gene delivery vectors, and recent clinical trials have shown promising results. cenocepacia activated a signaling complex that required the adapter molecule MyD88. beta(2)GPI bound FXI in vitro and inhibited its activation to FXIa by thrombin and FXIIa.

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The role of transmembrane chloride current in afterdepolarisations in canine ventricular cardiomyocytes. Toxoplasma gondii: a simple method for titration of infectivity with monolayer cells. Growth of at-risk managed care contracts between health plans and medical groups has been well documented, but less is known about the nature of financial incentives within those medical groups or their effects on health care utilization. Catheter-based thrombolysis is a safe and effective treatment of proximal deep venous thrombosis and might reduce the occurrence of postthrombotic syndrome compared to treatment with anticoagulation alone. An examination of three methods of psychodynamic formulation based on the same videotaped interview. Animal studies have shown that the dura mater contains mast cells. Endoscopic intervention for biliary leaks after laparoscopic cholecystectomy: a multicenter review.

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Phosphoinositide signaling presents a particularly intriguing network whose many mysteries are now being unlocked. Logistic regression and Odd Ratio calculations were used to identify factors that were associated with extended encounters with clients. In mouse, segregation of the primitive endoderm lineage from the pluripotent epiblast lineage depends on FGF/MAP kinase signaling, but it is unknown whether this is conserved between species. However, the supporting documentation is scant and of poor quality. Among women who complete treatment for the sequelae of childhood abuse, shifts to resolved attachment were indirectly related to decreases in interpersonal problems through improved emotional processing. Botulinum toxin, in therapeutic doses, is a remarkably safe drug with relatively few adverse effects. We conclude that significant traces of differential activation of antiviral transcriptional response can be found in three independent medulloblastoma patient cohorts. However, the effect of this absorption on the sound-field response can vary significantly, even when material properties of the structure and dimensions of the coupled system are not changed. In addition, DNA ligase I participates in a second BER pathway that is carried out by a multiprotein complex in which DNA ligase I interacts directly with DNA polymerase beta.

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Observations using laser confocal microscopy with lysosomal fluorescent probes showed that silkworm athrocytes, including pericardial cells, suboesophageal body, and peritracheal athrocytes, were rich in lysosomes, in contrast to other tissues. Due to different Au-X interactions, halide has been demonstrated to display different switching behaviors to the catalytic activity of protein-modified AuNPs. Energy, proteins, carbohydrates, total lipids, minerals, vitamins, linoleic acid contents were calculated. While exploring possible mechanisms of PTEN effects on NGF signaling, we discovered a significant down-regulation of both high-affinity (TrkA) and low-affinity (p75) NGF receptors in PTEN-overexpressing clones. The results of treatment of 60 children with complete adhesive ileus (CAI), occurring from 6 mo till 10 yrs after appendectomy conduction, were analyzed. This study evaluates the use of short interval MRI rather than immediate CT or biopsy. Molecular identification of naturally acquired strongylid infections in lambs--an investigation into how lamb age influences diagnostic sensitivity. The resulting (2 S,4 R)-4-hydroxyproline (Hyp) residues are essential for the folding, secretion, and stability of the collagen triple helix. In this work, we present the ontology we have developed for pandemic influenza policy models.

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Immunohistochemical and ultrastructural study of a papillary cystadenocarcinoma arising from the sublingual gland. This article introduces the concept of optimal identification (OI), which utilizes a global inversion algorithm to extract the full distribution of parameters consistent with the laboratory data. In the experiments, RysannMD achieved the best median F1 measure across the benchmarking corpora, independent of the standard used (silver/gold), biomedical subdomain, and document size. JNK (c-Jun N-terminal kinase) is a member of the MAPK (mitogen-activated protein kinase) family that regulates a range of biological processes implicated in tumorigenesis and neurodegenerative disorders. Sensory symptoms, typically affecting the face and arm, were the most common presentation. No significant change was found in the Km between suspensions and cultures. This study shows that trophoblastic cells belonging to the endovascular subpopulation express considerable amounts of HLA-G and slightly less HLA-C. In this metaanalysis, overall diagnostic performance of FDG-PET was moderate to high. The patient presented transitory neutropenia and reduced C4 levels but subsequent study of immune defects was normal.

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To evaluate the metabolic profiles of adolescents with different phenotypes of polycystic ovary syndrome (PCOS). In that case the displacement of the probe at a fixed position of the detector produces a unique and linear response only in a restricted region of the probe displacement, usually several hundred nanometers. Besides the well known radical-cationic Feelisch-Schoenafinger pathway, an alternative anionic route via a neutral radical is proposed and included in the study. The authors identified a specific group of patients who have normal or prominent malar projection in the presence of atrophy of the buccal fat pad, with or without prominent gonial angles. Thus, for patients undergoing operations not associated with substantial blood loss, the results of preoperative collagen-induced whole blood platelet aggregation are not effective in identifying patients likely to experience excessive blood loss. Use of an oral burn splint following perioral electrical burns in children is a widely accepted treatment.

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Positron emission tomography (PET) was used to investigate human episodic memory for spatial location and object identity. Samples were processed for transmission electron microscopy and western blot. In the carton-pouring task, the standard deviation for the whole population was 16.0 degrees for flexion-extension, 3.4 degrees for radial-ulnar deviation and 10.7 degrees for pronation-supination. Clinical manifestations of ESES are heterogeneous: apart from different seizure types, they consist in combinations of cognitive, motor, and behavioural disturbances associated with a peculiar electroencephalographic pattern of paroxysmal activity significantly activated during slow sleep, which culminates in a picture of continuous spikes and waves during sleep (CSWS). Their results as of summer 2011 are presented in the following article. Solicited adverse events were monitored by parental observation and were recorded on a diary card. The effect of elective caesarean section could not be separated from the effect of antiviral therapy. Public disclosure of health care performance reports: a response from the UK. Hilar and mediastinal lymphadenectomy was performed in every patient. Active site-inactivated factor VIIa inhibits nuclear factor kappa B activation in intestinal ischemia and reperfusion.

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Apart from her aphasia she showed several other disturbances of higher cortical functions in the acute phase of the illness. Sorption and desorption by ideal two-compartment systems: unusual behavior and data interpretation problems. Risk factors of local oropharyngeal and laryngeal adverse effects from use of single inhaled corticosteroids and long-acting beta-agonists. An improved fabrication strategy via asymmetric functionalization is also described, assisted by solid phase synthesis which minimizes the formation of trimers and multimers. Moreover, we describe a direct method to measure the arginine catabolism using thin-layer chromatography. Metabolic predictions were generated using homology modeling, cDNA-expressed p450 enzymes, human liver microsomes, primary cultured human hepatocytes, and precision-cut human liver slices. Together, these results indicate that the AT cell lines utilized in this study are not hypersensitive to the oxidant. Cation interdiffusion model for enhanced oxygen kinetics at oxide heterostructure interfaces. A 43-year-old woman had abdominal pain and anemia due to inorganic lead poisoning.

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Nutritional guidance for infants and toddlers is lacking, and the diets of American children in the first 2 years of life are not well characterized. In this retrospective study a model to predict treatment was developed based on cases of self-poisoning in 1996 and validated on cases between 1997 and 1999. We obtained data concerning migration, medical history, exposure to classical risk factors for hepatitis B infection, socioeconomic factors, and the habit of sharing a bed or personal objects. Optic canals were separated by a septum of variable thickness dividing the posterior part of the canal into a large canal in the usual position and a smaller one inferior to it. Dopaminergic vasodilation in the choroidal circulation by d1/d5 receptor activation. Insecticidal activity of Stemona collinsiae root extract against Parasarcophaga ruficornis (Diptera: Sarcophagidae). Satellite males may therefore have AVT reserves that might allow them to call depending on the social conditions. To identify factors associated with early treatment discontinuation of three agents commonly prescribed for women with low bone density. Longitudinal analysis of serum KL-6 levels in patients with systemic sclerosis: association with the activity of pulmonary fibrosis. Though other risks need to be weighed (eg, sedation, intubation, radiation exposure), this result may enable more liberal utilization of CTA for preoperative surgical planning of congenital heart operations in patients with unclear or complex anatomy.

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For the analysis techniques we present, we evaluate improvement in modeling accuracy via 10-fold cross-validation. Some technical features made the procedure easier in perivesical infiltration and adhesive process in the upper abdominal cavity. Plasmons in graphene can be tuned by using electrostatic gating or chemical doping, and the ability to confine plasmons in very small regions could have applications in optoelectronics, plasmonics and transformation optics. A pre-peak was separated from the main peak of a monoclonal antibody by size exclusion HPLC (SE-HPLC) analysis using two TSK-Gel G3000SWXL columns connected in series. Finally, the ability of Gly-533 mutants to efficiently process omega-5 allylic substrates suggests that the top channel does not serve as a product exit route indicating that oxygenated substrate diffuses from the cyclooxygenase active site in a membrane proximal direction. The cancer status of parents and grandparents was compared for 48 animals with colon cancer and 58 controls, all with histological confirmation of ulcerative colitis. Does the presence of morphine counteract adaptive changes in expression of G-protein alpha subunits mRNA induced by chronic morphine treatment?. The most common aetiology was road traffic accidents (RTA), followed by sport traumas.

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Double-blind clinical trial accomplished on 236 patients of age lower than 7 months and hospitalizad with diagnosis of acute bronchiolitis, first episode, in a pediatric department in Madrid.The patients were randomized in two groups: those who have received maneuvers of chest physiotherapy and those who have received maneuvers placebo. Validation of quantitative structure-activity relationship (QSAR) model for photosensitizer activity prediction. Here, we present improved 3D analyses of normal murine ears during embryonic development using optical sections obtained through Thin-Sheet Laser Imaging Microscopy. Finally, consistent with the murine data, we found that there is an analogous reduction in Notch gene expression in arterioles from humans with mutations in CCM1. Blood pressure variables derived by ambulatory monitoring are important prognostic markers in hypertensive patients. In both groups, the mean sick leave frequency slightly decreased over time (intervention effects were not significant). One of these last patients developed and adult type rheumatoid arthritis during her evolution and was treated with D-penicillamine. Isolation and characterization of polymorphic microsatellites for silver pomfret. Effect of sprinkling on feedlot microclimate and cattle behavior.

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These factors should be considered for the design of interventions to sustain and promote the adoption of smoking bans in the home among this and other populations. CNS diseases can result in long hospital stays, reduced quality of life and marked disability. This analysis revealed that it is essential to include the entropic contribution in modeling equilibrium behavior. It is then possible to record and reconstruct holographic images at an extremely low signal level. Definitive treatment involves trapping of the internal carotid artery either by a direct approach, or by balloon embolization. Patients with mild to moderate vascular dementia receiving memantine 20 mg/day had less cognitive deterioration at is glyburide safe while breastfeeding 28 weeks but again this effect was not clinically discernible.

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A catenary curve is used to approximate the overall curvature of the breast contour, and the curvature measure is extracted from the catenary curve. We suggest by consequence to consider a therapeutic strategy including the treatment of both disorders for an optimal therapeutic response. IOP-reducing treatment was unrelated to the presence or ventolin evohaler 100 mg frequency of disc hemorrhages. Union-management solutions for preventing workplace injury of older workers. Sample of this study included 36 863 people aged 35 years or more who came from a cohort consisting three communities from Tiantan Hospital, Puren Hospital and the Gymnasium Road Hospital in Beijing, based on the surveys on the Integrated Community Intervention Measures of Cerebro-vascular Diseases. E-cadherin expression on fine-needle aspiration biopsies in primary lung adenocarcinomas is related to tumor differentiation and invasion. Key facilitators were enrollment in health insurance, prior relationship and familiarity with hospital personnel, and positive experience in healthcare setting.

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Hypophosphatasia (HPP) is a rare disorder with a wide range of clinical manifestations. The primary improvement results from a more adequate representation of the crash occurrence process by incorporating crash precursor events into the modeling framework. Information was also collected on the reasons why women were not enrolled, either because they refused or had a contraindication. A contralateral approach laterally expands the accessible infratentorial area. As risk stratification may aid in prophylaxis and treatment, we explored risk factors for severe PONV in patients enrolled in a large international, randomized controlled trial (the ENIGMA trial). Our present theory is that maturation of Pep5 involves (a) enzymic conversion of Thr, Ser and Cys into dehydrated amino acids and zyrtec 100 mg sulfide bridges, (b) membrane translocation and cleavage of the modified prepeptide. In contrast, if the plasma membrane vesicles were first treated with diluted hydrogen peroxide or oxidized glutathione (GSSG) and then assayed for NADH oxidase activity, the antitumor sulfonylurea stimulated the activity. Attendees reported improved quality and value with increased EB CME.

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Interventional musculoskeletal ultrasonography of the lower limb. Downward migration of radiocaesium in organic soils across a transect in Scotland. Radiofrequency (RF) ablation and cryoablation are increasingly being used as minimally invasive treatments for renal malignancies. Analysis of potential risk factors for early postoperative pulmonary infection after pediatric living donor liver transplantation. Furthermore, co-incubation with a broad-spectrum protein kinase C (PKC) inhibitor, such as bisindolylmaleimide (Bis), also partially reversed protection from apoptosis, and examination of a panel of PKC inhibitors suggested a role for atypical isozymes in protection. An audit of prostate-specific antigen and clinical symptoms in general practice. The somatosensory system is a suitable model for studying the manner in which presentation of a single physical variable (e.g. However, recent trends are toward increased use of endovascular endografting.

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Rats rendered chronically hyperprolactinemic by implantation of extra anterior pituitary glands (AP) under the kidney capsule have excess urinary calcium excretion. 3,4-dimethoxyphenyl bis-benzimidazole, a novel DNA topoisomerase inhibitor that preferentially targets Escherichia coli topoisomerase I. The Medicaid expansion led to greater access and improved birth outcomes. Measles vaccine (MV) may have non-specific beneficial effects for child health and particularly seems to prevent respiratory infections. There seems to be room for improvement particularly in the cooperation between General Practitioners and counselling centres as well as between hospitals for substance abuse and aftercare institutions.

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These studies demonstrate that most CRISP1 interacts with sperm transiently, possibly with a specific receptor on the sperm surface, consistent with its action in suppressing capacitation during epididymal storage of sperm. The aim of this study was to clarify the role of apoptosis-regulating proteins (bcl-2, bax, cytochrome-c, and caspase-8) in septic rats by studying their expression in gastric and intestinal epithelial cells. Cytokine screening identifies NICU patients with Gram-negative bacteremia. Metabolic MRI of myocardial and hepatic triglyceride content in response to nutritional interventions. The past and present published studies reaffirm that nongonadal LH and hCG actions are real and here to stay. Contraction and expansion of the silicon scaffold of stable Si6R6 isomers. A case of 4 true knots in an umbilical cord, which did not cause any detectable harm, is presented.

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p16 protein expression and correlation with clinical and pathological features in osteosarcoma of the jaws: Experience of 37 cases. Malpractice claims regarding calls to Swedish telephone advice nursing: what went wrong and why?. The results demonstrate that there are multiple types of head movement tendencies, but some of these influence behavior across rather different experimental settings and tasks. Percutaneous catheterization is a frequently-used technique to gain access to the central venous circulation. Metabolic measurements, including serum-cholesterol, serum-triglycerides, fasting plasma-glucose, waist circumference, blood pressure and resting heart rate, as well as smoking and self-reported stress were related to the self-reported physical activity level, according to the modernized version of the SGPALS 4-level scale. It is unlikely that Gulf War veterans are suffering chronic effects from illnesses caused by chemical warfare nerve agent exposure. T-lymphocyte determinants were studied by fluorescence-activated cell sorter analysis (against controls). The parameters analyzed were tissue volume (TV), fractional trabecular bone volume (BV/TV) and fractional medullary fibrous volume (FbV/TV). The anatomy of these vessels, which had not previously been described in this species, was found not to differ significantly from the fundamental chelonian pattern.

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Acute cold exposure (-5 degrees C, 15 min) caused increases in plasma corticosterone, glucagon levels, and in BAT glucagon levels in all acclimated groups. A trough of lung cancer incidence rates was observed among men in 1935-39 birth-cohorts. Chronic antioxidant use and changes in endothelial dysfunction: a review of clinical investigations. Repeated peripheral stem cell mobilization in healthy donors: time-dependent changes in mobilization efficiency. aureus, by affecting protein synthesis and inhibiting leucine incorporation. Establishment of a transgenic cell model for preliminary screening of chemopreventive agents. Plankton DNA was identified in lung samples obtained from the non-drowned rabbits because of postmortem plankton penetration into the respiratory system, and plankton DNA was identified in liver and kidney samples obtained from the decomposed drown rabbits. Nerve conduction measurements in normal subjects are assumed to be symmetric, but the normal limits of symmetry have not been determined. It indicated that tinidazole-iodoform-phenocamphor paste had the same effect on controlling acute periapical periodontitis as that of formocresol. The size of the study was small and therefore cannot be claimed as being representative.

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