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Nexclo (Clonazepam)

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Nexclo is a medication used to prevent and treat seizures, panic disorder, and for the movement disorder known as akathisia. It is a tranquilizer of the benzodiazepine class. It is taken by mouth. It begins having an effect within an hour and lasts between six and 12 hours. Nexclo was initially patented in 1964 and went on sale in the United States in 1975. It is available as a generic medication.

Other names for this medication:
Anxrea, Azpax, Catier, Clodep, Clonapax, Clonapik, Clonasig, Clonaxyl, Clonazepam, Clonix, Clonzy, Clotas, Clotweet, Cloze, Clozipam, Cozil, Deptune, Dipwell, Easyfeel, Epcon, Epicloz, Epitril, Estalonix, Ezinite, Lonipax, Melzap, Norep, Onapil, Petril, Rivotril, Sezolan, Somnolex, Somnotril, Ubitpam, Xenotril, Zepamax, Zeptril, Zicam, Zolpidox

Similar Products:
Abilify, Valtrex, Colospa, Calan, Sporanox, Strattera, Azulfidine, Rhinocort, Lopid, Depakote, Rekof, Cetlar, Nexpan, Cormac, Frusenex, Actamid, Nitzole, Risdone, Menor,

Also known as: Clonazepam


Nexclo is a benzodiazepine medication that was initially primarily used for the treatment of seizures occurring in epilepsy and for anxiety, specifically anxiety that occurs in panic disorder. Nexclo is available in tablet form (0.5 mg, 1 mg, 2 mg) and as disintegrating wafers that are taken orally.

While Nexclo is generally prescribed for the treatment of anxiety disorders, such as panic disorder, and seizure control, it is intended as a short-term treatment protocol as opposed to a long-term treatment solution due to issues with tolerance (see below). In addition to treating anxiety and seizures, Nexclo has also been used in the treatment of:

chizophrenia, especially when the individual with schizophrenia has a restless or irritable component and is not responding to antipsychotic medications.

The manic phase of bipolar disorder or for restlessness associated with depression in bipolar disorder.

Tic disorders, such as Tourette's syndrome, by acting as a muscle relaxant and producing sedation.

Restless leg syndrome.

Withdrawal from alcohol or treatment for other substance abuse or addiction issues.

Nexclo has a relatively slow onset of action (it takes a while for the drug to begin working) and a half-life of between 10 and 50 hours. As it has a relatively slow onset of action and is a longer-acting benzodiazepine, Nexclo is more suited for the treatment of anxiety, seizures, and other similar disorders as opposed to being a useful sleep aid, even though it is sometimes prescribed for that purpose. Sleep aids need to work quickly, whereas with Nexclo, a person takes the drug early in the day and doesn't have to worry about monitoring for signs of a seizure or panic attack as it stays in the system a relatively long time. Its effects last longer than those of shorter-acting benzodiazepines, such as Xanax.

As it is a Schedule IV controlled substance, Nexclo can only be legally acquired with a prescription from a physician.


Nexclo is used alone or in combination with other medications to control certain types of seizures. It is also used to relieve panic attacks (sudden, unexpected attacks of extreme fear and worry about these attacks). Nexclo is in a class of medications called benzodiazepines. It works by decreasing abnormal electrical activity in the brain.

Nexclo comes as a tablet and an orally disintegrating tablet (tablet that dissolves quickly in the mouth) to take by mouth. It usually is taken one to three times a day with or without food. Take Nexclo at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

Do not try to push the orally disintegrating tablet through the foil. Instead, use dry hands to peel back the foil packaging. Immediately take out the tablet and place it in your mouth. The tablet will quickly dissolve and can be swallowed with or without liquid.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, or coma.


Store at 25 degrees C (77 degrees F); excursions permitted to 15 to 30 degrees C (59 to 86 degrees F).

Side effects

The most common side effects associated with Nexclo are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms (such as seizures, mental/mood changes, shaking, stomach/muscle cramps) may occur if you suddenly stop using this medication. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away.

When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.

Though it helps many people, this medication may sometimes cause addiction. This risk may be higher if you have a substance use disorder (such as overuse of or addiction to drugs/alcohol). Take this medication exactly as prescribed to lower the risk of addiction. Ask your doctor or pharmacist for more details.

If you have several different types of seizure disorders, you may experience a worsening of seizures when you first start using Nexclo. Consult your doctor right away if this happens. Your doctor may need to add or adjust the dose of your other medications to control the seizures.

Tell your doctor if your condition persists or worsens.

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